Just as oil is poured into static parts and machines, experts have now discovered a way to add lubricating fluid to arthritic knees, which can benefit arthritis patients.
A large number of people around the world, including in Pakistan, suffer from knee pain and only painkillers provide some relief after which people are able to walk.
Scientists at the University of Oklahoma have developed a lubricating substance, like a natural lubricant, to relieve joint spasms and keep them moving. When tested on mice, it not only improved the affected joints but also increased the growth of soft cartilage between the joints.
We know that during old age, smooth ligament bones penetrate between the knees and their fractures cause severe pain and discomfort. Then the rubber-like elastic part is affected, which increases the internal inflammation and pain. The scan and the report show that the natural fat-producing substance between them is also beginning to disappear.
In severe cases of arthritis, knee surgery is performed to remove broken bone fragments and smooth them out, which can lead to some improvement. If there is no cure, experimentally stem cells are also inserted which are made from the patient’s fat or blood.
Now, University of Oklahoma scientist Chuan Bin Mao and his colleagues focused on the natural fluid between the knee joints called the synovial fluid. Between the healthy joints of the knees is a liquid-based on large molecules. It also contains hyaluronic acid, some lipids, fats, and lubricants.
The lubrication sub-components stick to the water molecules while the rest of the lubricant is attached to the liquid cartilage. A thin layer of water is retained just above the cruciate ligament, which protects the friction of the bones in the movement of the knees.
Scientists have now chosen a molecule called PAMPS, which is an alternative liquid to natural fats. It contains a large amount of hyaluronic acid. Experimentally, when rats with knee pain were injected with this synthetic liquid, the intensity of friction and inflammation was found to be reduced.
Eight weeks after the rats were given artificial oil, the cartilage joints of the rats were examined under a microscope, much to the astonishment of experts. At this point, the crooked bones began to grow again. Thus, the regeneration of tissue began with the application of fat. Now, in the next step, it will be tested on larger animals or mammals.
